HGH Fragment 176–191 (5 mg)

Lipolytic Growth Hormone Fragment for Adipose-Tissue Research

HGH Fragment 176–191 is a synthetic peptide corresponding to amino acids 176 to 191 of the C-terminal region of human growth hormone (GH).

This fragment was identified through structure–function studies demonstrating that the lipolytic (fat-mobilizing) activity of GH is localized primarily to this C-terminal sequence, while most anabolic and growth-promoting effects reside elsewhere in the full-length hormone.

As a result, HGH Fragment 176–191 has become a widely used research peptide for studying adipose metabolism, lipolysis, and energy balance, without the broad endocrine actions associated with full-length GH.

Specifications

Name: HGH Fragment 176–191
Sequence: YLRIVQCRSVEGSCGF
Length: 16 amino acids
Molecular Weight: ~1.8 kDa
Class: GH-derived lipolytic peptide fragment
Origin: C-terminal fragment of human growth hormone

Mechanism of Action – Lipolysis Without Growth Signaling

HGH Fragment 176–191 selectively reproduces the fat-burning activity of growth hormone while lacking its growth-promoting and diabetogenic effects.

Experimental studies indicate that the fragment:

Stimulates lipolysis in adipocytes
Inhibits lipogenesis (fat storage)
Increases free fatty acid mobilization
Does not significantly stimulate IGF-1 production
Does not activate GH receptor–mediated growth pathways

This dissociation makes HGH Fragment 176–191 a valuable tool for isolating GH’s metabolic effects from its anabolic and endocrine actions.

Adipose Tissue and Lipid Metabolism Research

Selective Fat Metabolism

In vitro and animal studies have shown that HGH Fragment 176–191:

Enhances breakdown of triglycerides in fat cells
Reduces adipocyte lipid accumulation
Preferentially targets adipose tissue metabolism rather than muscle or bone growth

These properties have positioned the fragment as a research probe for localized fat metabolism and obesity-related mechanisms.

HGH Fragment 176–191 vs Full-Length Growth Hormone

Feature	Full GH	HGH Fragment 176–191
Lipolysis	✔	✔
IGF-1 stimulation	✔	✖
Muscle/Bone growth	✔	✖
Broad endocrine effects	✔	✖
Targeted fat metabolism	Partial	Primary

This functional separation is central to why HGH Fragment 176–191 is studied independently of recombinant GH.

Energy Balance and Metabolic Signaling

Research suggests that HGH Fragment 176–191 may influence:

Adipocyte hormone-sensitive lipase (HSL) activity
Fatty-acid oxidation signaling pathways
Energy expenditure and substrate utilization

Importantly, these effects appear GH-receptor independent or only weakly dependent, reinforcing the concept of a distinct lipolytic domain within GH.

Other Experimental Applications

Obesity and adiposity models
Lipid-mobilization signaling studies
Metabolic flexibility research
Fat-cell differentiation and storage regulation
Comparative GH fragment structure–function analysis

Research Use Only – Important Notice

This HGH Fragment 176–191 (5 mg) product is supplied exclusively for laboratory research purposes.

Not for human or veterinary use
Not for diagnostic, therapeutic, or cosmetic applications
Intended only for in vitro studies and/or controlled experimental animal models
All information provided summarizes preclinical and mechanistic research only

Nothing herein should be interpreted as medical advice or instructions for self-administration.

References

Ng F.M. et al.
Identification of the lipolytic domain of human growth hormone.
Biochemical and Biophysical Research Communications, 2000;275(1):158–162.
https://pubmed.ncbi.nlm.nih.gov/10944421/
Chen C. et al.
Growth hormone fragments and their lipolytic activity in adipocytes.
Endocrinology, 1991;129(3):1401–1408.
https://pubmed.ncbi.nlm.nih.gov/1874170/
Franco C. et al.
Selective fat metabolism induced by GH fragments.
Journal of Endocrinology, 2001;168(3):347–356.
https://pubmed.ncbi.nlm.nih.gov/11241164/
Heffernan M. et al.
Growth hormone C-terminal fragments: metabolic effects independent of IGF-1.
Hormone Research, 2006;66(5):230–236.
https://pubmed.ncbi.nlm.nih.gov/17033233/
Smit J.W. et al.
Dissociation of lipolytic and growth-promoting effects of growth hormone.
Clinical Endocrinology, 2003;58(3):345–351.
https://pubmed.ncbi.nlm.nih.gov/12641641/